Integration of Subthreshold and Suprathreshold Excitatory Barrages along the Somatodendritic Axis of Pyramidal Neurons
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چکیده
منابع مشابه
Integration of Subthreshold and Suprathreshold Excitatory Barrages along the Somatodendritic Axis of Pyramidal Neurons
Neurons integrate inputs arriving in different cellular compartments to produce action potentials that are transmitted to other neurons. Because of the voltage- and time-dependent conductances in the dendrites and soma, summation of synaptic inputs is complex. To examine summation of membrane potentials and firing rates, we performed whole-cell recordings from layer 5 cortical pyramidal neurons...
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The firing evoked by injection of simulated barrages of EPSCs into the proximal dendrite of layer 5 pyramidal neurons is greater than when comparable inputs are injected into the soma. This boosting is mediated by dendritic Na+ conductances. However, the presence of other active conductances in the dendrites, some of which are nonuniformly distributed, suggests that the degree of boosting may d...
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We studied the subcellular correlates of spreading depression (SD) in the CA1 rat hippocampus by combining intrasomatic and intradendritic recordings of pyramidal cells with extracellular DC and evoked field and unitary activity. The results demonstrate that during SD only specific parts of the dendritic membranes are deeply depolarized and electrically shunted. Somatic impalements yielded near...
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Differences in behavioral roles, anatomical connectivity, and gene expression patterns in the dorsal, intermediate, and ventral regions of the hippocampus are well characterized. Relatively fewer studies have, however, focused on comparing the physiological properties of neurons located at different dorsoventral extents of the hippocampus. Recently, we reported that dorsal CA1 neurons are less ...
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Canals, S., I. Makarova, L. López-Aguado, C. Largo, J. M. Ibarz, and O. Herreras. Longitudinal depolarization gradients along the somatodendritic axis of CA1 pyramidal cells: a novel feature of spreading depression. J Neurophysiol 94: 943–951, 2005. First published March 30, 2005; doi:10.1152/jn.01145.2004. We studied the subcellular correlates of spreading depression (SD) in the CA1 rat hippoc...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0033831